Furthermore, data from the ProActive UK trial in adults with T2DM family history showed that objectively measured moderate- and vigorous-intensity physical activity predicted insulin resistance independent of sex, age, waist circumference, smoking status, self-reported TV viewing and time spent sedentary and at light-intensity activity; thus, highlighting the benefits of promoting at least moderate-intensity physical activity (e.g. brisk walking) on insulin sensitivity in such high-risk populations [51]. The gene discussed is INS; the disease is type 2 diabetes mellitus.