Moreover, a population-based study in middle-aged adults with 5.6 years of follow-up (Medical Research Council Ely study, 1994–2003) showed that objectively measured sedentary time may also predict insulin resistance at follow-up, even after adjustment for moderate- and vigorous-intensity physical activity levels, and independently of baseline age, sex, fat mass, smoking status, fasting insulin levels and follow-up time [52]. The gene discussed is INS; the disease is Insulin resistance.