The most important aspects of “BRCAness” phenotype chosen from literature were as follows: deficiency in HR, high genomic instability, frequent P53 mutations, but infrequent PI3K mutations in breast and ovarian cancers, in addition to basal like classification and high probability of pathological complete response (pCR) in breast cancers [6, 7, 28, 38, 39, 41, 42]. Here, PIK3CA is linked to breast cancer.