Combined with these independent research results, it is strong suggest that FN1 (R534P), PROS1 ((K200I), (Q571K)), SCEL (T320S), SLC34A2 (T688M) and TENM1 (S1131F) are potential novel biomarker candidates significantly associated with thyroid carcinomas and could differentiate the malignant thyroid nodule among cytological indeterminate cases. The gene discussed is TENM1; the disease is thyroid gland carcinoma.