The 16 genes were matched in 37 (4.0%) of 915 patient’s cases with genetic alternation of missense mutation, amplification, deep deletion and copy- number alterations, and listed as CC2D2B, CFH, CITED1, FN1, GOS2, GABRB2, KRT19, TENM1, PPP2R2B, PROS1, RXRG, SCEL, SERGEF, SLC34A2 and STK32A. Some of these generic alternations were associated with papillary thyroid carcinoma metastasis to brain [34] and could be useful as histopathological biomarkers for papillary thyroid carcinoma [25, 35]. The gene discussed is PROS1; the disease is thyroid gland papillary carcinoma.