In addition, the queried results also discovered 5 genes with missense mutation significantly (P value < 0.01) associated thyroid cancer cases, listed as FN1 (R534P), PROS1 ((K200I), (Q571K)), SCEL (T320S), SLC34A2(T688M) and TENM1 (S1131F) (Fig. 4b). The gene discussed is SCEL; the disease is thyroid cancer.