The most frequently mutated genes were KRAS (11.4%), NRAS (7.0%), FLT3 (7.0%), and KMT2D (5.3%) in B-ALL, whereas NOTCH1 (23.1%), FBXW7 (23.1%), PHF6 (11.5%) and PTEN (11.5%) were enriched in T-ALL. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.