In addition, KMT2D can interact with KMT2A in acute myeloid leukemia, its deletion reduced MLL-AF9 leukemia cell survival, and the codeletion of both KMT2A and KMT2D resulted in more severe reductions in survival, proliferation, and gene expression than either individual gene deletion [50]. Here, KMT2A is linked to acute myeloid leukemia.