PHF6 and acute lymphoblastic leukemia: However, it is interesting that 2 cases with PHF6 mutations co-occurred with NOTCH1 mutations and were significantly correlated with the NOTCH1 mutation in Chinese adult T-ALL (PHF6 mutNOTCH1mut vs PHF6 wtNOTCH1mut, 75.0% vs 44.2%; P = 0.035) [37].