Six representative pathways about SUPV3L1 were “Dilated cardiomyopathy (DCM)”, “ECM-receptor interaction”, “Glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulfate”, “Malaria”, “Protein digestion and absorption” and “Regulation of lipolysis in adipocytes”, Six representative pathways about SLC22A17 were “Apelin signaling pathway”, “Cushing syndrome”, “MAPK signaling pathway”, “Oxytocin signaling pathway”, “PI3K-Akt signaling pathway” and “Platelet activation” (Fig. 4). The gene discussed is APLN; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.