BRCA1 and ovarian cancer: In this study, we performed (i) next-generation sequencing (NGS) to determine the mutational state of BRCA1/2 in ovarian cancer tissues from 98 consecutive patients with HGSOC; (ii) compared the results to the known germline BRCA1/2 mutational state by conventional Sanger sequencing of blood samples; and (iii) determined the genetic landscape of somatic mutations in HGSOC tumors.