We have previously reported the histopathological changes after the administration of bevacizumab (anti-VEGF-A monoclonal antibody) using actual human glioblastoma specimens resected in 3 different settings: glioblastomas before any treatment; glioblastomas resected following bevacizumab therapy; and recurrent glioblastomas after long-term bevacizumab therapy [26, 27, 33]. The gene discussed is VEGFA; the disease is glioblastoma.