The results showed that constitutive levels of cytokines including IL-4, IL-5, IL-13, TNF-α, IFN-γ, or IL-17 were relatively low in the SC of untreated control mice, whereas they were dramatically elevated in lesional SCs of AD mice that were repeatedly exposed to Ox (Figure 4A–F). The gene discussed is IFNG; the disease is Alzheimer disease.