Yet, EWSR1 break-apart occurs in several morphological mimics of EwS such as DSRCT harboring a pathognomonic EWSR1-WT1 fusion, and angiomatoid fibrous histiocytoma (AFH) commonly positive for EWSR1-ATF1 fusions (Figure 1). Here, EWSR1 is linked to desmoplastic small round cell tumor.