Regarding the role of EWS-FLI1 in regulating YAP signaling in EWs, He and Coll have demonstrated that EWS-FLI1 oncoprotein enhances tenascin expression by directly binding to its promoter region and that integrin α5β1-mediated YAP activation may be responsible for expression of YAP targets’ genes that are implicated in EWs tumor progression [82]. The gene discussed is YAP1; the disease is neoplasm.