The 2-AG synthesis is reduced during the ictal phase of the epileptic process in patients with temporal lobe epilepsy, and this reduction might be due to impaired expression of Diacil glycerol lipase and degradation enzymes (Monoacylglycerol lipase and α/β-hydrolase) that undergo alteration leading to a decreased release of GABA [74,75]. The gene discussed is MGLL; the disease is temporal lobe epilepsy.