BIN1 acts as a negative regulator of DNM2 activity during muscle maturation and modulation of DNM2 intracellular levels alleviates the requirement for BIN1 since Bin1−/− Dnm2+/− mice were alive and did not suffer from myopathy whereas the Bin1−/− KO mice were not viable [273]. The gene discussed is DNM2; the disease is myopathy.