Most importantly, TCGA-derived data unveiled 6% of muscle-invasive UBC cases (bladder cancer, “amplification” and “mRNA high”, Cell 2017, z: 1.5) to be carrying upregulated levels of TMSB10 gene (encodes Tβ10) expression (https://www.cbioportal.org), thus indicating the in vivo importance of Tβ10 (and Tβ4) to UBC progression toward high-malignancy grades and aggressive metastatic stages that are characterized by resistance to (chemo/radio)therapy, shorter survival of patients, and, generally, poor prognosis. The gene discussed is TMSB10; the disease is urinary bladder cancer.