Pdx-1-Cre, LSL-KrasG12D/+ double mutant mice show pre-cancerous pancreatic intraepithelial neoplasias (PanIN), and Pdx-1-Cre,LSL-KrasG12D/+, LSL-Trp53R172H/+ (KPC) triple mutant transgenic mice develop the invasive pancreatic ductal adenocarcinoma [22,23]. Here, PDX1 is linked to pancreatic ductal adenocarcinoma.