TP53 and B-cell chronic lymphocytic leukemia: Interestingly, TP53 disruption is not associated with a shorter TTFT, in line with the notion that TP53 disruption interacts with treatment with chemotherapeutic agents, but not with a watch and wait strategy that does not expose CLL cells carrying TP53 disruption to the positive selection pressure exerted by ineffective chemotherapy [55,56].