ABCA1 and atherosclerosis: Since CUR intake affected the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and prevented atherosclerosis in apoE−/− mice, it was proposed that inhibition of SR-A-mediated oxLDL uptake and promotion of ABCA1-dependent cholesterol efflux represent two crucial events in cholesterol accumulation suppression by CUR in macrophage foam cells transformation [118].