We found the induction of p‐STAT3 was coincident with reduction of ratio of LC3‐II/LC3‐I in IL‐6 stimulated H9c2 cells and in TAC mice at the earlier stage, but at the later stage in TAC mice up‐regulation of p‐STAT3 was accompanied by increased ratio of LC3‐II/LC3‐I. Here, STAT3 is linked to persistent truncus arteriosus.