REN and hydrops fetalis: Compared with placebo, ARBs and direct renin inhibitors (DRIs) are not beneficial in decreasing the rate of efficacy outcomes including death, cardiovascular death, non‐fatal myocardial infarction, HF hospitalization and composite of cardiovascular death or HF hospitalization when HF therapy is not enough.10 Given the poor prognosis and the staggering social burden HHD and HF exert, a better understanding of the precise mechanism of HHD and HF merits accelerated investigation.11