A review about the understanding of STAT3 in autophagy summarized that different modified or localized STAT3 exhibited pro‐ or anti‐autophagy function in transcription‐dependent and transcription‐independent manner in various circumstances.57 Inhibition of STAT3 could lead to induction of lipidation of LC3A resulting in up‐regulation of autophagy in glioma cells.58 However, the mechanisms underlying how STAT3 plays context‐dependent role in autophagy is yet to be elucidated. Here, STAT3 is linked to central nervous system cancer.