In addition to the pro‐hypertrophic role of IL‐6 in rats, IL‐6 deficiency was found to attenuate AngII induced cardiac pathology33, 34 and excessive activation of gp130 induces myocardial hypertrophy in mice.19 In contrary to the notion that IL‐6 might be pro‐hypertrophic and fibrotic, Kaminski et al and Lai et al21, 22 considered IL‐6 as non‐essential in cardiac hypertrophy using IL‐6 knockout mice. This evidence concerns the gene AGT and cardiac hypertrophy.