DICER1 and neoplasm: The reasons for this discrepancy can only be speculated on, but since endogenous DICER1 protein expression in this cell line is low, augmentation of DICER1 expression might give rise to a greater dose-dependent effect than what would be seen if depleting already low levels of DICER1. A recent study of DICER1 in PTC by Ramírez-Moya and co-workers showed that down-regulation of DICER1 promoted proliferation, migration, invasion and epithelial-mesenchymal transition through miRNA down-regulation and that DICER1 indeed can act as a tumour suppressor (Ramirez-Moya et al. 2019).