Activation of the PI3K/Akt pathway have also been observed in FTC (Hou et al. 2007), and recent studies have also identified mutations and aberrant methylation in the telomerase reverse transcriptase (TERT) promoter region, as well as TERT copy number gains and expression which have also been associated with a poor prognosis (Liu et al. 2014, Wang et al. 2014, Liu & Xing 2016, Paulsson et al. 2018). Here, TERT is linked to thyroid cancer, nonmedullary, 2.