DUX4 and facioscapulohumeral muscular dystrophy: This result suggests that unlike the role of p38 inhibitors in suppressing DUX4 in cellular and animal models of facioscapulohumeral muscular dystrophy (Oliva et al., 2019), this pathway does not play a major role in the regulation of Dux upon RS induction in mouse ESC (Figure 2—figure supplement 1k; Figure 2—source data 1).