Previous studies have shown that FGF2 can promote the growth of malignant tumors via autocrine and paracrine pathways and that it plays an important role in tumor migration.20 Berger et al. 21 first confirmed the existence of an FGF2‐FGFR autocrine ring in NSCLC, and this abnormal activation was associated with poor prognosis. The gene discussed is FGF2; the disease is neoplasm.