Furthermore, we used validated measures of disease, previously shown for both asthma31 and definition of type 1 diabetes using insulin prescription.2 In addition, the genetically informative design based on the identification and linkage of 5 types of relatives within our cohort allowed us to suggest familial coaggregation, thereby exploring the possibility of shared familial risk factors underlying the association between asthma and type 1 diabetes. The gene discussed is INS; the disease is type 1 diabetes mellitus.