CASP3 and cervical carcinoma: When both cervical cancer cells were treated with 2.5, 5.0 and 10.0 ng/ml of Colchicine for 48 h, the protein expression levels of Bax, cleaved caspase 3 and cytochrome c in cytosolic fraction were increased in a dose-dependent manner, whereas the Bcl-2 protein expression was in the opposite manner (Figure 5A,B).