Figure 6c shows a representative example of a hyperactive response in a KC, in which a 1 s odor pulse elicited an average of 7 spikes (Figure 6d and e). Figure 6f shows spike times obtained from 10 other KC-odor pairs. Overall, the distribution of spike counts in KCs we tested in vivo was clustered close to 0 but included a long rightward tail (Figure 6g), in agreement with our model (Figure 6a). The gene discussed is TBCE; the disease is keratoconus.