It has anti‐inflammatory properties3 and acts as a calcium channel blocker in the heart.4, 5, 6, 7 STC‐1 is present in the serum of healthy pregnant but not non‐pregnant women and is further elevated in pregnancies complicated by preeclampsia.8 Although the expression of the gene is detected in placental tissue and peaks mid‐gestation, the cellular origin was not reported.8 Collectively these results suggest that STC‐1 not only has a role in maintaining a healthy pregnancy but may also play a part in the pathology of common pregnancy complications. This evidence concerns the gene STC1 and preeclampsia.