In fact, it has been reported that hypoglycemia is associated with a higher risk of dementia,23,24 and a significant relationship between postprandial hyperglycemia/acute glucose fluctuations and cognitive impairments has been observed.29,30 To add, studies of the relationship between the hyperglycemia markers hemoglobin A1C (HbA1C) and glycated albumin and the risk of dementia have been published.24,31,32 Therefore, the control of blood sugar fluctuations is considered to be very important to lower the risk of AD in patients with T2DM.33,34. This evidence concerns the gene ALB and Alzheimer disease.