In the context of HCC, Zhong et al53 showed that the SMARCA4 single nucleotide polymorphism rs11879293, which was located in the intron between exon 1 and exon 2 of SMARCA4 and was essential for the interaction between SMARCA4 and SS18L1/CREST, showed a remarkable association with a reduced risk of HCC, as verified in stage 2 combined analysis. Here, SS18L1 is linked to hepatocellular carcinoma.