Frequent inactivating mutations in SWI/SNF subunits, such as ARID1A, ARID1B, ARID2, PBRM1 and SMARCA4, are repeatedly detected in numerous cancers (Figures 1 and 2).9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23. This evidence concerns the gene SMARCA4 and cancer.