ARID2 expression is reported to be dramatically down‐regulated in HCC tissues compared with their normal counterparts, and it physically interacts with the E2 promoter binding factor 1 (E2F1), decreasing the binding of E2F1/RNA Pol II to the promoters of cyclin D1 (CCND1) and cyclin E1 (CCNE1). This evidence concerns the gene CCND1 and hepatocellular carcinoma.