B-cell lymphomas often harbor reciprocal chromosomal translocations that juxtapose the immunoglobulin (Ig) loci and proto-oncogenes (e.g., c-myc) (Wang et al., 2008; Wang et al., 2009), or mutations of non-Ig genes that are targets of AID (Kuppers, 2005; Chen and Wang, 2014). Here, MYC is linked to B-cell non-Hodgkin lymphoma.