The recent STRASS study of RA-patients in remission (DAS28 < 2.6) found that relapse was observed more frequently in patients placed on a progressively increased spacing of TNF-blockers injections than those maintained on their previous dosing regimen (76.6% vs 46.5%, p = 0.0004), however the equivalence of the two strategies could not be demonstrated due to an underpowered trial [23]. This evidence concerns the gene TNF and rheumatoid arthritis.