Variants in genes that cause EDS or EDS‐like phenotypes such as SLC39A13, B4GALT7, COL3A1, COL5A1, and COL5A2 showed a trend of approximately twofold increased frequency in cases compared with controls (p = 0.031) (Table 2). This evidence concerns the gene COL5A2 and Ehlers-Danlos syndrome.