Also of note, the EDS gene set showed significant associations with low BMD, which is compatible with the clinical observation that cohorts of EDS patients displayed significantly increased prevalence of vertebral fractures.36, 37, 38 Of the EDS genes we examined, SLC39A13 and B4GALT7 are known to cause spondylodysplastic EDS, where short stature and pathognomonic radiological findings were included as the diagnostic criteria.39 The inclusion of skeletal findings for the EDS diagnosis suggests convergence of the biological pathways regulating skeletal, tendon, ligament, and skin development. The gene discussed is SLC39A13; the disease is spondylodysplastic Ehlers-Danlos syndrome.