CDC73 and tumor of parathyroid gland: After removal of a single parathyroid tumor, he developed severe hungry bone syndrome and required 3 weeks of continuous i.v. calcium infusion, in addition to oral calcium and activated vitamin D. Histopathological examination identified an angioinvasive parathyroid carcinoma with global loss of parafibromin (protein encoded by <i>CDC73/HRPT2</i>)<i>.</i>HRpQCT and DXA studies were obtained prior to surgery and 18-months postsurgery.