The study of Abdelrahman and collaborators showed that enhancement of NK cell cytotoxicity by miR-182 in human hepatocellular carcinoma and increased Prf1 expression were indirect effects likely mediated by a complex modulation of NKG2D and NKG2A levels in these cells at different stages of the disease (Abdelrahman et al., 2016) (Figure 1B). This evidence concerns the gene PRF1 and hepatocellular carcinoma.