For example, IL-2-based immunotherapy allows NK cells to override inhibitory signals from acute myeloid leukemia (AML) blasts (Hallner et al., 2019), and recently, immunotherapies based on the use of therapeutic monoclonal antibodies specific for iNKRs, in particular anti-pan-KIR2D (lirilumab) (Romagne et al., 2009; Kohrt et al., 2014; Vey et al., 2018) and anti-NKG2A (monalizumab), have been developed (André et al., 2018; Tinker et al., 2019; Zaghi et al., 2019). This evidence concerns the gene KLRC1 and acute myeloid leukemia.