TLR4 and neoplasm: Moreover, the activation of TLR4 signaling by lipopolysaccharide profoundly increased the EMT in pancreatic cancer cells (Figure 2) and IL-10 increases cancerous the expression of inhibitor of PP2A (CIP2A) via the phosphatidylinositide 3-kinases (PI3K) signaling pathway and promotes tumor aggressiveness in lung adenocarcinoma (38, 39).