In the tumor microenvironment, TAMs secrete cytokines such as IL-10, transforming growth factor-β (TGF-β) and inflammatory mediators, including prostaglandin E2 (PGE2) and matrix metalloproteinase-7 (MMP-7), to inhibit the normal process of antigen-presenting, which makes T cells lose their competence in recognizing and even killing tumor cells. This evidence concerns the gene TGFB1 and neoplasm.