Although the role of REV1 overexpression in human carcinogenesis remains poorly understood, human cells overexpressing REV1 exhibit a comparable to the abovementioned phenotype, with enhanced mutation frequency and hindered cell death, therefore, it can be clearly stated that regulation of Rev1 levels is required for maintaining genomic stability and tumor suppression (Table 2) [47]. The gene discussed is REV1; the disease is neoplasm.