The miR-125b–STAT3 axis has a reported involvement in tumor cell proliferation, apoptosis and migration, for example, in osteosarcoma cells [17], liver, lung and colorectal cancer cells [32], melanoma cells [33], laryngeal and oral squamous cell carcinoma cells [34, 35], and cervical cancer cells [36]. Here, STAT3 is linked to osteosarcoma.