CXCR1 and cancer: In the following sections, we will illustrate how zebrafish embryonic development helped to unravel fundamental chemokine signaling mechanisms and discuss in detail the roles of zebrafish chemokine receptors Cxcr1/2, Cxcr3.2/3.3, Cxcr4b, Ackr3b, and Ccr2 in macrophage and neutrophil biology in the context of cancer and wound and pathogen-driven inflammation.