DuMont et al. demonstrated rounding, detachment, and death of A549 cells, an adenocarcinoma human alveolar epithelial cell line, mediated via degradation of ECM components such as type I collagen and fibronectin by the major and minor extracellular proteases StmPr1 and StmPr2 (17, 42). This evidence concerns the gene FN1 and adenocarcinoma.