According to Miyagi et al. (43), our data indicate that elevated phosphorylation of STAT1 over STAT4 after IFN-α stimulation should result in induction of ISG expression (i.e., STAT1 and TRAIL), enhancement of degranulation, and poor IFN-γ production in HCV patients with cirrhosis. The gene discussed is STAT1; the disease is Cirrhosis.