Interestingly, the expression levels of HMGB1 in the uterus are lowest during the expected time of implantation, and exogenous administration of HMGB1 leads to pregnancy failure accompanied by induction of inflammatory responses in rats, indicating a role of excessive extracellular HMGB1 in PE as well as infertility (120). The gene discussed is HMGB1; the disease is Infertility.