In parallel, mDCs induce the IL-12/IFN-γ cytokine axis, which is responsible for the strong type II IFN transcriptomic signature and the high frequency of Th1 and Tc1 cells in both psoriasis plaques and peripheral blood of patients (Schlaak et al., 1994; Austin et al., 1999). This evidence concerns the gene IFNG and psoriasis.