An animal experiment shows that after stroke, the level of GDNF in the ischemic hemisphere of rats treated with levodopa increased, implicating that GDNF is involved in the mechanism of tissue reorganization and plasticity, and participates in the enhanced recovery of brain function loss by levodopa (Kuric et al., 2013), which provides overwhelming evidences that central nervous system development is of vital importance to ischemia stroke, so neuroprotective agent after stroke is considered a crucial pharmacological approach (Chechneva et al., 2014; de Oliveira et al., 2019). Here, GDNF is linked to stroke disorder.