Further, we found that linc02042 was also overexpressed in ESCC plasma in comparison to healthy control plasma (Fig. 1c), and the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) value was 0.9294 (95%CI 0.8638 to 0.9949) (Fig. 1d), implying that plasma linc02042 has an excellent diagnostic efficacy for ESCC. The gene discussed is LINC02042; the disease is esophageal squamous cell carcinoma.