MAPT and early-onset autosomal dominant Alzheimer disease: This potentiation, revealed by the synergistic interaction between APOEε4 and amyloid-β, was associated with higher levels of tau pathology in the precuneus, posterior cingulate, anterior cingulate, inferior parietal, and basolateral temporal cortices, regions known to exhibit tau accumulation and neurodegeneration across the Alzheimer’s disease spectrum [14, 16, 38, 39].