Other genes with common variants were considered but not prioritized because of likely limited chemical space of substrates (HSD17B), small reduction in catalytic activity by the variant (GSTP1), unknown importance (HAAO), known substrate redundancy with related enzymes (GSTP1, SULTs), or too few LOH events in CRC (ABP1 and AKR7A). The gene discussed is GSTP1; the disease is colorectal carcinoma.