ENPEP and colorectal carcinoma: To enrich for kinase interactions that could explain the preferential killing of slow NAT2 cells, we compared the binding affinity of each kinase with APA and NAPA, selected 44 targets with preferential binding to APA and excluded kinases non-essential for cell survival and those not expressed in CRC cells (Supplementary Fig. 4A, Supplementary Table 4).