CSDE1 and melanoma: In sharp contrast, Drosophila UNR has been shown to repress translation when tethered to the 3′ UTR of msl-2 transcripts (34), and CSDE1 has been recently shown to promote the translation of select oncogenic mRNAs through binding to their 3′UTRs in melanoma cells (27), suggesting that the regulatory capacity of CSDE1 depends on the specific binding context and/or cellular factors.