Because both CK1 and APC have been linked to hyperexcitability and epilepsy (Howlett et al., 2013; Kowalski et al., 2014; Rodriguez et al., 2019), based on our study, Mdm2-p53 signaling perhaps functions downstream of CK1 and/or APC to mediate excitability. The gene discussed is APC; the disease is epilepsy.