Because the gene expression analysis indicated that Smarcad1 is involved in regulating multiple genes linked to innate immunity and inflammatory processes, we tested the response of the intestine epithelium-specific knockout mice in the well-established dextran sodium sulfate (DSS)-induced colitis model, as DSS-mediated colitis is thought to depend critically on innate immunity [44]. The gene discussed is SMARCAD1; the disease is colitis.