In the steady-state condition, we found that Smarcad1-KO promoted expression of several genes linked to innate immunity, such as Toll-like receptor Tlr4, anti-bacterial peptides, and other factors controlling inflammatory responses such as Lyz1. One gene that is highly overexpressed upon Smarcad1-KO in steady state and colitis is Mt1, coding for metallothionein. This evidence concerns the gene TLR4 and colitis.