In a study conducted by Yang et al. [7], it was illustrated that not only could BKM120 hinder colon cancer cell proliferation through FoxO3a-dependent PUMA induction, but it also potentiated the effect of either 5-fluorouracil or regorafenib on different colon cancer-derived cell lines. The gene discussed is FOXO3; the disease is malignant colon neoplasm.