Our data have revealed that the suppression of PI3K using BKM120 could remarkably reduce both the survival and the metabolic activity of the AML-derived KG-1 and U937 cell lines, which is in agreement with the results reported by Allegretti et al. [29], who showed a favorable antileukemic effect of the inhibitor against AML cells but not the normal counterpart. The gene discussed is PIK3CD; the disease is acute myeloid leukemia.