CD4 and diffuse large B-cell lymphoma: Moreover, since the R-CHOP chemotherapy regime was the standard therapy for DLBCL, we conducted a separate analysis of patients receiving R-CHOP to confirm the effects of these factors, including IPI scores of ≥3, high β2-MG level, elevated LDH level, and low CD4:CD8 ratio (<1) at diagnosis on prognosis.