ERN1 and breast cancer: A study by Wennemers reported that although most of the data make clear elevated TRIB3 mRNA level was associated with poor prognosis, but it was associated with a good prognosis in human breast cancer patients.28 The specific causes and mechanisms of these differences remain unclear, which may be related to the mechanism of TRIB3 participating in endoplasmic reticulum stress‐induced tumor cell apoptosis through CHOP/ATF4 pathway at the same time.29, 30 In addition, we found that knockout of SP2 significantly reduced the protein level of ATF6 but not PERK and IRE1.