HSPA5 and hepatocellular carcinoma: In order to further clarify the function of Sp2 in HCC and its relationship with ERS, IHC was used to detect the expression of ERS marker protein GRP78 in 95 cases of primary HCC and ANT liver tissues (Figure 5A), while WB method was used to detect 4 pairs of fresh HCC/ANT (Figure 5D).