Transcription factor Sp2 is a member of the SP protein family, which is involved in the regulation of cell proliferation, differentiation, apoptosis and other functions.10 Recent studies have shown that Sp2 may overexpress and play a crucial part in many kinds of cancers.11, 12 However, the role of Sp2 in HCC has not been studied. The gene discussed is SP2; the disease is hepatocellular carcinoma.