SPOP and Familial prostate cancer: Recent studies have shown that SPOP correlated with the mediation of the ubiquitin and subsequent oncogenic hormone receptor SRC‐3 proteolysis, which suggests that SPOP plays a specified role in the inhibition of tumour.8 Recent research analysis found that SPOP protein was frequently mutated in some tumours, such as endometrial cancer,9 lung cancer10 and prostate cancer.11 Our previous studies reported that SPOP also had a similar situation in colon cancer,12 but it was not very clear in GC.