By some previous studies, we noticed that lncRNA ADAMTS9‐AS2 may be strongly associated with some important cancer‐related genes.23 In this study, combining bioinformatics analyses, we discovered the down‐regulation of ADAMTS9‐AS2 and SPOP in GC cells and revealed that ADAMTS9‐AS2 could positively regulate the expression of SPOP. The gene discussed is SPOP; the disease is cancer.