SPOP and gastric cancer: Moreover, in our study, we demonstrated that overexpression of ADAMTS9‐AS2 could up‐regulate the expression of SPOP, thus suppressing cell growth, proliferation, promote apoptosis and block cell cycle progression of GC and spheroid formation of tumorsphere cells, which suggested that ADAMTS9‐AS2 played a crucial role in inhibiting GC progression by targeting SPOP.