Besides, SPOP is a 374‐amino acid protein that comprises a POZ domain downstream of the predicted TD, which has been previously positioned in the nucleus in speckled mode.22 SPOP is now considered a tumour suppressor because its expression has been shown to inhibit SRC‐3–mediated carcinogenic signalling and carcinogenesis.8 A recently published study showed that SPOP suppressed gastric cancer cell invasion and proliferation by regulating Hh/Gli2 signalling pathway.14 But so far, there is no research demonstrated that SPOP expression focuses on gastric CSCs. Here, GLI2 is linked to neoplasm.